Title : Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection.

Pub. Date : 2022 Apr 15

PMID : 35440680






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection. Mitoxantrone surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Here, we show that Mitoxantrone, an FDA-approved topoisomerase inhibitor, targets a heparan sulfate-spike complex to compromise the fusogenic function of spike in viral entry. Mitoxantrone surface glycoprotein Severe acute respiratory syndrome coronavirus 2
3 Here, we show that Mitoxantrone, an FDA-approved topoisomerase inhibitor, targets a heparan sulfate-spike complex to compromise the fusogenic function of spike in viral entry. Mitoxantrone surface glycoprotein Severe acute respiratory syndrome coronavirus 2