Pub. Date : 2022 Apr 15
PMID : 35440680
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane proteins on the cell surface. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane proteins on the cell surface. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 4 | Here, we show that Mitoxantrone, an FDA-approved topoisomerase inhibitor, targets a heparan sulfate-spike complex to compromise the fusogenic function of spike in viral entry. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 5 | Here, we show that Mitoxantrone, an FDA-approved topoisomerase inhibitor, targets a heparan sulfate-spike complex to compromise the fusogenic function of spike in viral entry. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |