Title : A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways.

Pub. Date : 2022 Apr 19

PMID : 35440579






2 Functional Relationships(s)
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1 The clinical introduction of the Bruton"s tyrosine kinase (BTK) inhibitor ibrutinib, which targets B-cell antigen-receptor (BCR)-controlled integrin-mediated retention of malignant B cells in their growth-supportive lymphoid organ microenvironment, provided a major breakthrough in lymphoma and leukemia treatment. ibrutinib Bruton tyrosine kinase Homo sapiens
2 The clinical introduction of the Bruton"s tyrosine kinase (BTK) inhibitor ibrutinib, which targets B-cell antigen-receptor (BCR)-controlled integrin-mediated retention of malignant B cells in their growth-supportive lymphoid organ microenvironment, provided a major breakthrough in lymphoma and leukemia treatment. ibrutinib Bruton tyrosine kinase Homo sapiens