Title : Novel DNA Aptamer for CYP24A1 Inhibition with Enhanced Antiproliferative Activity in Cancer Cells.

Pub. Date : 2022 Apr 27

PMID : 35436103






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have identified a novel 70-nt DNA aptamer-based inhibitor of CYP24 by utilizing the competition-based aptamer selection strategy, taking CYP24 as the positive target protein and CYP27B1 (the enzyme catalyzing active vitamin D3 production) as the countertarget protein. Cholecalciferol cytochrome P450 family 27 subfamily B member 1 Homo sapiens