Title : Pepstatin analogues as novel renin inhibitors.

Pub. Date : 1986 Jul

PMID : 3543358






1 Functional Relationships(s)
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1 The analogues having a Phe residue in place of Val1 (X) and His or amino acid with an aliphatic side chain such as norleucine or norvaline in the Y position showed the highest inhibition of human plasma renin activity with IC50 values of about 10(-8)M. Esterification or amidification of the carboxyl group of the C-terminal statine did not change the inhibitory potency. Histidine renin Homo sapiens