Pub. Date : 2022 Mar 21
PMID : 35431500
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-alpha-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells. | Quercetin | tumor necrosis factor | Homo sapiens |
| 2 | METHODS: The normal human gastric mucosa epithelial cell line GES-1 was used to establish a normal human gastric epithelial cell model of TNF-alpha-induced MMP-9 protein overexpression to evaluate the anti-inflammatory effects of quercetin. | Quercetin | tumor necrosis factor | Homo sapiens |
| 3 | Quercetin and TNF-alpha antagonists decreased the TNF-alpha-induced phosphorylation of c-Src, ERK1/2, c-Fos, and p65 in a dose- and time-dependent manner. | Quercetin | tumor necrosis factor | Homo sapiens |
| 4 | Quercetin, TNF-alpha antagonist, PP1, U0126, and tanshinone IIA (TSIIA) reduced TNF-alpha-induced c-Fos phosphorylation and AP-1-Luciferase (Luc) activity in a dose- and time-dependent manner. | Quercetin | tumor necrosis factor | Homo sapiens |
| 5 | Pretreatment with quercetin, TNF-alpha antagonist, PP1, U0126, or Bay 11-7082 reduced TNF-alpha-induced p65 phosphorylation and translocation and p65-Luc activity in a dose- and time-dependent manner. | Quercetin | tumor necrosis factor | Homo sapiens |
| 6 | TNF-alpha significantly increased GES-1 cell migration, and these results were reduced by pretreatment with quercetin or a TNF-alpha antagonist. | Quercetin | tumor necrosis factor | Homo sapiens |
| 7 | CONCLUSION: Quercetin significantly downregulates TNF-alpha-induced MMP-9 expression in GES-1 cells via the TNFR-c-Src-ERK1/2 and c-Fos or NF-kappaB pathways. | Quercetin | tumor necrosis factor | Homo sapiens |