Title : Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells.

Pub. Date : 2022

PMID : 35418865






4 Functional Relationships(s)
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1 Here, we demonstrate that Ag120 (ivosidenib), a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor approved for the treatment of certain cancers, acts as an ASCT2 inhibitor in CRC cells. ivosidenib isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Here, we demonstrate that Ag120 (ivosidenib), a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor approved for the treatment of certain cancers, acts as an ASCT2 inhibitor in CRC cells. ivosidenib isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
3 Here, we demonstrate that Ag120 (ivosidenib), a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor approved for the treatment of certain cancers, acts as an ASCT2 inhibitor in CRC cells. ivosidenib isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
4 Here, we demonstrate that Ag120 (ivosidenib), a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor approved for the treatment of certain cancers, acts as an ASCT2 inhibitor in CRC cells. ivosidenib isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens