Pub. Date : 2022 Apr 13
PMID : 35418176
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Osteopontin promotes hepatocellular carcinoma progression through inducing JAK2/STAT3/NOX1-mediated ROS production. | Reactive Oxygen Species | NADPH oxidase 1 | Homo sapiens |
| 2 | Mechanistically, OPN induced ROS production in HCC cells by upregulating the expression of NADPH oxidase 1 (NOX1). | Reactive Oxygen Species | NADPH oxidase 1 | Homo sapiens |
| 3 | Mechanistically, OPN induced ROS production in HCC cells by upregulating the expression of NADPH oxidase 1 (NOX1). | Reactive Oxygen Species | NADPH oxidase 1 | Homo sapiens |
| 4 | In addition, NOX1 overexpression increased JAK2 and STAT3 phosphorylation by increasing ROS production, creating a positive feedback loop for stimulating JAK2/STAT3 signaling induced by OPN. | Reactive Oxygen Species | NADPH oxidase 1 | Homo sapiens |