Title : NAD+ Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy.

Pub. Date : 2022 Mar 22

PMID : 35408818






1 Functional Relationships(s)
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1 More importantly, through constitutively overexpressing NMNAT1 or NAMPT in human mesangial cells, we revealed NAD+ levels altered inversely with NMN levels in the context of DN and, further, their changes affect Sirt1/NF-kappaB P65, thus playing a crucial role in the pathogenesis of DN. NAD nicotinamide nucleotide adenylyltransferase 1 Homo sapiens