Title : Repurposing Dipyridamole in Niemann Pick Type C Disease: A Proof of Concept Study.

Pub. Date : 2022 Mar 22

PMID : 35408815






1 Functional Relationships(s)
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1 Dipyridamole significantly reduced cholesterol accumulation in fibroblasts and rescued mitochondrial deficits; the mechanism elicited by dipyridamole relies on activation of the adenosine A2AR subtype subsequent to the increased levels of extracellular adenosine due to the inhibition of ENT1. Dipyridamole adenosine A2a receptor Homo sapiens