Pub. Date : 2022 Jun
PMID : 35404148
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BRCA1 expression associated with the prognostic value of platinum-based chemotherapy for stage II-IV non-small cell lung cancer: A meta-analysis. | Platinum | BRCA1 DNA repair associated | Homo sapiens |
| 2 | PURPOSE: To explore the relationship between breast cancer susceptibility gene 1 (BRCA1) expression and the prognostic value of platinum-based chemotherapy for stage II-IV non-small cell lung cancer (NSCLC). | Platinum | BRCA1 DNA repair associated | Homo sapiens |
| 3 | METHODS: PubMed, Web of Science, Embase, and Cochrane Library were searched from inception to August 2021, for retrieving literature related to BRCA1 expression and prognostic value of platinum-based chemotherapy in NSCLC patients. | Platinum | BRCA1 DNA repair associated | Homo sapiens |
| 4 | Compared with the low BRCA1 expression, its high expression negatively affected the overall survival of NSCLC patients treated with platinum-based chemotherapy (hazard ratio (HR) = 1.53, 95% confidence interval (CI): 1.01-2.31, P < 0.05). | Platinum | BRCA1 DNA repair associated | Homo sapiens |
| 5 | CONCLUSION: BRCA1 expression is correlated with the prognostic value of platinum-based chemotherapy for stage II-IV NSCLC patients. | Platinum | BRCA1 DNA repair associated | Homo sapiens |
| 6 | In Caucasian population, compared with low BRCA1 expression, its high expression has a negative effect on the overall survival and event-free survival in stage II-IV NSCLC patients after platinum-based chemotherapy; however, this correlation was not found in China. | Platinum | BRCA1 DNA repair associated | Homo sapiens |