Title : Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence.

Pub. Date : 2022 Apr 7

PMID : 35391601






3 Functional Relationships(s)
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1 Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence. nitazoxanide surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Here, we demonstrate that nitazoxanide, an antiprotozoal agent with recognized broad-spectrum antiviral activity, interferes with SARS-CoV-2 spike maturation, hampering its terminal glycosylation at an endoglycosidase H-sensitive stage. nitazoxanide surface glycoprotein Severe acute respiratory syndrome coronavirus 2
3 Nitazoxanide, being equally effective against the ancestral SARS-CoV-2 Wuhan-spike and different emerging variants, including the Delta variant of concern, may represent a useful tool in the fight against COVID-19 infections. nitazoxanide surface glycoprotein Severe acute respiratory syndrome coronavirus 2