Pub. Date : 2022 Apr 7
PMID : 35391601
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence. | nitazoxanide | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
2 | Here, we demonstrate that nitazoxanide, an antiprotozoal agent with recognized broad-spectrum antiviral activity, interferes with SARS-CoV-2 spike maturation, hampering its terminal glycosylation at an endoglycosidase H-sensitive stage. | nitazoxanide | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
3 | Nitazoxanide, being equally effective against the ancestral SARS-CoV-2 Wuhan-spike and different emerging variants, including the Delta variant of concern, may represent a useful tool in the fight against COVID-19 infections. | nitazoxanide | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |