Pub. Date : 2022 Jul 15
PMID : 35390471
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Additionally, QYS treatment also upregulated the silent mating type information regulation 2 homolog 1 (SIRT1), peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), fibronectin III domain containing protein 5 (FNDC5), brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB), and mitogen-activated protein kinase (MAPK) proteins. | Hydroxyzine dihydrochloride | brain derived neurotrophic factor | Mus musculus |
| 2 | Additionally, QYS treatment also upregulated the silent mating type information regulation 2 homolog 1 (SIRT1), peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), fibronectin III domain containing protein 5 (FNDC5), brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB), and mitogen-activated protein kinase (MAPK) proteins. | Hydroxyzine dihydrochloride | brain derived neurotrophic factor | Mus musculus |
| 3 | CONCLUSIONS: Our study indicated that QYS had a good anti-social defeat stress effect on CSDS-induced depression in mice, mainly through SIRT1/PGC-1alpha/FNDC5/BDNF-TrkB signaling pathway activation. | Hydroxyzine dihydrochloride | brain derived neurotrophic factor | Mus musculus |