Title : Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis.

Pub. Date : 2022 Apr 5

PMID : 35385726






1 Functional Relationships(s)
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1 AR blockade with enzalutamide induces (1) transcriptional silencing of TP53 and hence dedifferentiation to a hybrid epithelial and mesenchymal and stem-like state and (2) inhibition of BMP signaling, which promotes resistance to AR inhibition. enzalutamide tumor protein p53 Homo sapiens