Title : Templated insertions are associated specifically with BRCA2 deficiency and overall survival in advanced ovarian cancer.

Pub. Date : 2022 Apr 6

PMID : 35385581






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1 We find that templated insertions (TINS) consistent with TMEJ repair are highly specific to tumors with pathogenic bi-allelic mutations in BRCA2 and that high TINS genomic signature content in advanced ovarian cancers associate with overall survival following treatment with platinum agents. Platinum BRCA2 DNA repair associated Homo sapiens