Pub. Date : 2022 May
PMID : 35380741
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PSMG3-AS1 enhances glioma resistance to temozolomide via stabilizing c-Myc in the nucleus. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 2 | We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 3 | We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 4 | We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 5 | We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 6 | We also demonstrated that PSMG3-AS1 mediates the resistance of GBM to TMZ, as knockdown of PSMG3-AS1 remarkably increased the sensitivity whereas overexpression of PSMG3-AS1 in sensitive GBM cell line induced a resistance phenotype to TMZ. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 7 | Mechanistically, PSMG3-AS1 directly binds to c-Myc and thus stabilizes c-Myc in the nucleus to promote the survival of GBM cells under treatment of TMZ. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 8 | Our data demonstrated an unreported role of PSMG3-AS1 in TMZ resistance and provide a potential novel target to tackle TMZ resistance in GBM. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |
| 9 | Our data demonstrated an unreported role of PSMG3-AS1 in TMZ resistance and provide a potential novel target to tackle TMZ resistance in GBM. | Temozolomide | proteasome assembly chaperone 3 | Homo sapiens |