Title : Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts.

Pub. Date : 2022 Apr 4

PMID : 35378512






1 Functional Relationships(s)
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1 Downregulation of IGFBP5 via siRNA in P2 MEFs increased the number of SA-beta-GAL-positive cells, upregulated p16 and p19, and inhibited cell growth. beta-D-galactose insulin-like growth factor binding protein 5 Mus musculus