Title : Mammalian Ddi2 is a shuttling factor containing a retroviral protease domain that influences binding of ubiquitylated proteins and proteasomal degradation.

Pub. Date : 2022 May

PMID : 35358511






2 Functional Relationships(s)
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1 We show that blocking Ddi2"s endoprotease activity either genetically or with the HIV protease inhibitor nelfinavir increased its binding to ubiquitin conjugates, but decreased its binding to proteasomes, and reduced subsequent protein degradation by proteasomes leading to further accumulation of ubiquitin conjugates. Nelfinavir cyanamide hydratase Saccharomyces cerevisiae S288C
2 Finally, nelfinavir treatment required Ddi2 to induce the unfolded protein response. Nelfinavir cyanamide hydratase Saccharomyces cerevisiae S288C