Title : [DEK-targeting aptamer DTA-64 inhibits epithelial-mesenchymal transition of airway epithelial cells in bronchial asthmatic mice via blocking TGF-β1 signaling pathway].

Pub. Date : 2022 Feb

PMID : 35356877






1 Functional Relationships(s)
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1 Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin. deoxythymidylyl-3'-5'-deoxyadenylate actin alpha 2, smooth muscle, aorta Mus musculus