Title : Telmisartan is the most effective ARB to increase adiponectin via PPARĪ± in adipocytes.

Pub. Date : 2022 May 10

PMID : 35354667






2 Functional Relationships(s)
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1 GW9662, a PPARgamma antagonist, completely blocked pioglitazone (PPARgamma agonist)-induced adiponectin secretion and mRNA expression, whereas it unexpectedly blocked neither telmisartan- nor irbesartan-induced adiponectin secretion and mRNA expression, but rather increased them. 2-chloro-5-nitrobenzanilide adiponectin, C1Q and collagen domain containing Homo sapiens
2 GW9662, a PPARgamma antagonist, completely blocked pioglitazone (PPARgamma agonist)-induced adiponectin secretion and mRNA expression, whereas it unexpectedly blocked neither telmisartan- nor irbesartan-induced adiponectin secretion and mRNA expression, but rather increased them. 2-chloro-5-nitrobenzanilide adiponectin, C1Q and collagen domain containing Homo sapiens