Title : A phase 1 study of IDH305 in patients with IDH1R132-mutant acute myeloid leukemia or myelodysplastic syndrome.

Pub. Date : 2022 Mar 30

PMID : 35353219






4 Functional Relationships(s)
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Protein Name
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1 PURPOSE: Isocitrate dehydrogenase enzyme 1 (IDH1) mutations at 132nd amino acid residue (R132*) result in the cellular accumulation of the oncometabolite, 2-hydroxyglutarate (2-HG). alpha-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 PURPOSE: Isocitrate dehydrogenase enzyme 1 (IDH1) mutations at 132nd amino acid residue (R132*) result in the cellular accumulation of the oncometabolite, 2-hydroxyglutarate (2-HG). alpha-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
3 PURPOSE: Isocitrate dehydrogenase enzyme 1 (IDH1) mutations at 132nd amino acid residue (R132*) result in the cellular accumulation of the oncometabolite, 2-hydroxyglutarate (2-HG). alpha-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
4 PURPOSE: Isocitrate dehydrogenase enzyme 1 (IDH1) mutations at 132nd amino acid residue (R132*) result in the cellular accumulation of the oncometabolite, 2-hydroxyglutarate (2-HG). alpha-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens