Title : Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity.

Pub. Date : 2022 Mar 4

PMID : 35336938






3 Functional Relationships(s)
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1 The spike proteins of enveloped viruses are transmembrane glycoproteins that typically undergo post-translational attachment of palmitate on cysteine residues on the cytoplasmic facing tail of the protein. Cysteine surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Here, we report that palmitoylation of the first five cysteine residues of the C-terminal cysteine-rich domain of the SARS-CoV-2 S protein are indispensable for infection, and palmitoylation-deficient spike mutants are defective in membrane fusion. Cysteine surface glycoprotein Severe acute respiratory syndrome coronavirus 2
3 Here, we report that palmitoylation of the first five cysteine residues of the C-terminal cysteine-rich domain of the SARS-CoV-2 S protein are indispensable for infection, and palmitoylation-deficient spike mutants are defective in membrane fusion. Cysteine surface glycoprotein Severe acute respiratory syndrome coronavirus 2