Pub. Date : 2022 Mar 25
PMID : 35331214
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Elevated plasma sphingolipids were associated with AR, TP53, RB1 and PI3K aberrations (p < 0.05). | Sphingolipids | tumor protein p53 | Homo sapiens |
2 | Furthermore, aggressive-variant prostate cancer (AVPC), defined as 2 or more aberrations in TP53, RB1 and/or PTEN, was associated with elevated sphingolipids. | Sphingolipids | tumor protein p53 | Homo sapiens |
3 | CONCLUSIONS: Elevated circulating sphingolipids were associated with AR, TP53, RB1, PI3K and AVPC aberrations in mCRPC, and the combination of lipid and genetic abnormalities conferred a worse prognosis. | Sphingolipids | tumor protein p53 | Homo sapiens |