Title : Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer.

Pub. Date : 2022 Mar 25

PMID : 35331214






3 Functional Relationships(s)
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1 Elevated plasma sphingolipids were associated with AR, TP53, RB1 and PI3K aberrations (p < 0.05). Sphingolipids tumor protein p53 Homo sapiens
2 Furthermore, aggressive-variant prostate cancer (AVPC), defined as 2 or more aberrations in TP53, RB1 and/or PTEN, was associated with elevated sphingolipids. Sphingolipids tumor protein p53 Homo sapiens
3 CONCLUSIONS: Elevated circulating sphingolipids were associated with AR, TP53, RB1, PI3K and AVPC aberrations in mCRPC, and the combination of lipid and genetic abnormalities conferred a worse prognosis. Sphingolipids tumor protein p53 Homo sapiens