Title : Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy.

Pub. Date : 2022 Mar 20

PMID : 35326731






2 Functional Relationships(s)
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1 Although activating T-cells is regarded as the primary anti-tumor mechanism of anti-CTLA-4 therapies, mounting evidence in the literature suggests targeting intra-tumoral Tregs as the primary mechanism of action of these agents. tregs cytotoxic T-lymphocyte associated protein 4 Homo sapiens
2 Anti-CTLA-4 therapy can enhance the priming of T-cells by blockading CD80/86-CTLA-4 interactions or depleting Tregs through antibody-dependent cellular cytotoxicity and phagocytosis. tregs cytotoxic T-lymphocyte associated protein 4 Homo sapiens