Title : Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism.

Pub. Date : 2022 Mar 23

PMID : 35322809






1 Functional Relationships(s)
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1 Treatment of Chkb-/- myocytes with peroxisome proliferator-activated receptor agonists enables fatty acids to be used for beta-oxidation and prevents triacyglyerol accumulation, while simultaneously increasing expression of the compensatory choline kinase alpha (Chka) isoform, preventing muscle cell injury. triacyglyerol choline kinase beta Mus musculus