Title : Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC β-Lactamase.

Pub. Date : 2022 Apr 19

PMID : 35311523






1 Functional Relationships(s)
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1 Herein, the basis of susceptibility to carbapenems and resistance to ceftazidime (CAZ) and CZA of the D179Y variant of KPC-2 and -3 was explored. avibactam, ceftazidime drug combination carbapenem-hydrolyzing beta-lactamase KPC-2 Klebsiella pneumoniae