Title : Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy.

Pub. Date : 2022 Mar 18

PMID : 35304456






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1 We describe herein a thermosensitive co-polymer hydrogel system formed from biocompatible polymers gelatin and Pluronic F127 that are widely used in humans to enable the sustained release of a nitric oxide donor and antibody blocking immune checkpoint cytotoxic T-lymphocyte-associated protein-4 for efficient and durable anti-tumor immunotherapy. Polymers cytotoxic T-lymphocyte associated protein 4 Homo sapiens