Title : Direct cardiac effects of SGLT2 inhibitors.

Pub. Date : 2022 Mar 18

PMID : 35303888






3 Functional Relationships(s)
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1 We postulate that cardiac benefit modulated by SGLT2i"s can be commonly attributed to their inhibition of sodium-loaders in the plasma membrane (NHE-1, Nav1.5, SGLT) affecting intracellular sodium-homeostasis (the sodium-interactome), thereby providing a unifying view on the various effects reported in separate studies. Sodium solute carrier family 9 member A1 Homo sapiens
2 We postulate that cardiac benefit modulated by SGLT2i"s can be commonly attributed to their inhibition of sodium-loaders in the plasma membrane (NHE-1, Nav1.5, SGLT) affecting intracellular sodium-homeostasis (the sodium-interactome), thereby providing a unifying view on the various effects reported in separate studies. Sodium solute carrier family 9 member A1 Homo sapiens
3 We postulate that cardiac benefit modulated by SGLT2i"s can be commonly attributed to their inhibition of sodium-loaders in the plasma membrane (NHE-1, Nav1.5, SGLT) affecting intracellular sodium-homeostasis (the sodium-interactome), thereby providing a unifying view on the various effects reported in separate studies. Sodium solute carrier family 9 member A1 Homo sapiens