Title : Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-γ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases.

Pub. Date : 2022 Jun

PMID : 35297512






1 Functional Relationships(s)
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1 Our results indicate that in DCs co-stimulated with LPS and IFN-gamma, but not with LPS alone, Tofacitinib leads to the decreased expression of IL-23/IL-12 shared subunit IL12B (p40). tofacitinib interleukin 9 Homo sapiens