Title : Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure.

Pub. Date : 2022 May

PMID : 35278430






1 Functional Relationships(s)
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1 Additionally, specific knockout of endothelial JMJD3 delayed EC regeneration, enhanced endothelial mesenchymal transition, impaired endothelial barrier function as determined by increased Evans blue staining and inflammatory cell infiltration, and accelerated neointima formation in the AVF created by venous end to arterial side anastomosis in CKD mice. Evans Blue KDM1 lysine (K)-specific demethylase 6B Mus musculus