Title : Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors.

Pub. Date : 2022 Mar 3

PMID : 35269938






3 Functional Relationships(s)
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1 The inhibition of physiological and purified recombinant furin by screening selected compounds, Clexane, and these drugs in combination with CMK was assayed in fluorogenic tests by using a specific furin substrate. Enoxaparin furin, paired basic amino acid cleaving enzyme Homo sapiens
2 In fluorogenic assays, these two compounds and Clexane inhibited both physiological and recombinant furin in a dose-dependent way. Enoxaparin furin, paired basic amino acid cleaving enzyme Homo sapiens
3 In conclusion, we identified Kukoamine A, Zeaxanthin, and Clexane as new furin inhibitors. Enoxaparin furin, paired basic amino acid cleaving enzyme Homo sapiens