Title : Novel sequential therapy with metformin enhances the effects of cisplatin in testicular germ cell tumours via YAP1 signalling.

Pub. Date : 2022 Mar 9

PMID : 35264157






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Further study showed that metformin blocked the cells in G1 phase by inducing phosphorylated YAP1 and reducing the expression of cyclin D1, CDK6, CDK4 and RB, which enhanced the chemosensitivity of cisplatin and activated the expression of cleaved caspase 3 in TGCTs. Metformin caspase 3 Homo sapiens