Pub. Date : 2022 Mar
PMID : 35263388
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficking from late endosomes and lysosomes to the endoplasmic reticulum. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | We found that reovirus infection is significantly impaired in cells lacking NPC1, but infection is restored by treatment of cells with hydroxypropyl-beta-cyclodextrin, which binds and solubilizes cholesterol. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | These findings suggest that cholesterol homeostasis, ensured by NPC1 transport activity, is required for reovirus penetration into the cytoplasm, pointing to a new function for NPC1 and cholesterol homeostasis in viral infection. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | These findings suggest that cholesterol homeostasis, ensured by NPC1 transport activity, is required for reovirus penetration into the cytoplasm, pointing to a new function for NPC1 and cholesterol homeostasis in viral infection. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |