Pub. Date : 2022 May 28
PMID : 35257833
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. | Fructose | solute carrier family 2 member 5 | Homo sapiens |
| 2 | Compensating for this, fructose was flexibly utilized by tumor cells as an alternative energy source to maintain proliferation and exert chemotherapy resistance in vitro by upregulating GLUT5, a major fructose transporter encoded by SLC2A5. | Fructose | solute carrier family 2 member 5 | Homo sapiens |
| 3 | Compensating for this, fructose was flexibly utilized by tumor cells as an alternative energy source to maintain proliferation and exert chemotherapy resistance in vitro by upregulating GLUT5, a major fructose transporter encoded by SLC2A5. | Fructose | solute carrier family 2 member 5 | Homo sapiens |
| 4 | Mechanistically, in glucose-deprived but fructose-rich environments, GLUT5 could interact with ketohexokinase and inhibit its autophagy-dependent degradation, thus trapping fructose into glycolysis and tricarboxylic acid cycle for the malignant growth of CRC cells. | Fructose | solute carrier family 2 member 5 | Homo sapiens |
| 5 | Mechanistically, in glucose-deprived but fructose-rich environments, GLUT5 could interact with ketohexokinase and inhibit its autophagy-dependent degradation, thus trapping fructose into glycolysis and tricarboxylic acid cycle for the malignant growth of CRC cells. | Fructose | solute carrier family 2 member 5 | Homo sapiens |
| 6 | Taken together, our findings highlight the role of elevated fructose utilization mediated by the GLUT5-KHK axis in governing CRC growth and imply that efforts to refine fructose intake or inhibit fructose-mediated actions may serve as potential therapeutic strategies. | Fructose | solute carrier family 2 member 5 | Homo sapiens |