Title : PPAR-α knockout leads to elevated blood pressure response to angiotensin II infusion associated with an increase in renal α-1 Na+/K+ ATPase protein expression and activity.

Pub. Date : 2022 May 1

PMID : 35245523






1 Functional Relationships(s)
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1 In contrast, angiotensin II decreased the expression (64-97% reduction in band density) of sodium-hydrogen exchanger-3 (NHE3), NHE regulatory factor-1 (NHERF1, Slc9a3r1), sodium-potassium-2-chloride cotransporter (NKCC2), and epithelial sodium channel (ENaC) beta- and gamma- subunits in the renal cortex of both WT and PPAR-alpha KO mice, with no difference between genotypes. Potassium solute carrier family 9 (sodium/hydrogen exchanger), member 3 Mus musculus