Title : Hydrogen sulfide attenuates cigarette smoke‑induced pyroptosis through the TLR4/NF‑κB signaling pathway.

Pub. Date : 2022 May

PMID : 35234268






2 Functional Relationships(s)
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1 The cellular experiments also revealed that CS induced the pyroptosis of the cells in a NLRP3/gasdermin D (GSDMD)-dependent manner. Cesium NLR family pyrin domain containing 3 Homo sapiens
2 In addition, H2S significantly attenuated the effects of CS extract (CSE) on pyroptosis, cell viability and the expression levels of pyroptosis-related proteins, indicating that H2S inhibited pyroptosis by decreasing NLRP3 expression and promoting GSDMD activation. Cesium NLR family pyrin domain containing 3 Homo sapiens