Pub. Date : 2022
PMID : 35222388
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A 4-Benzene-Indol Derivative Alleviates LPS-Induced Acute Lung Injury Through Inhibiting the NLRP3 Inflammasome. | 4-benzene-indol | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | The results showed that 4-benzene-indol derivative could not only suppress the activation of NLRP3 inflammasome both in vitro and alleviate LPS-induced ALI in vivo but also suppress the NLRP3 inflammasome in human myeloid leukemia mononuclear cells (THP-1) cell lines. | 4-benzene-indol | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | The results showed that 4-benzene-indol derivative could not only suppress the activation of NLRP3 inflammasome both in vitro and alleviate LPS-induced ALI in vivo but also suppress the NLRP3 inflammasome in human myeloid leukemia mononuclear cells (THP-1) cell lines. | 4-benzene-indol | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | To summarize, this research indicated that the newly-discovered 4-benzene-indol derivative targets NLRP3 inflammasome signaling, which consequently alleviates sepsis-related ALI. | 4-benzene-indol | NLR family pyrin domain containing 3 | Homo sapiens |