Pub. Date : 2022 Feb 14
PMID : 35216194
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SARS-CoV-2 infection elicits a polyclonal neutralizing antibody (nAb) response that primarily targets the spike protein, but it is still unclear which nAbs are immunodominant and what distinguishes them from subdominant nAbs. | nabs | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | To shed light on this issue, we gathered 83 structures of nAbs in complex with spike protein domains. | nabs | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | We analyzed in silico the ability of these nAbs to bind the full spike protein trimer in open and closed conformations, and predicted the change in binding affinity of the most frequently observed spike protein variants in the circulating strains. | nabs | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 4 | By comparing these fractions with those measured from plasma of infected patients, we showed that the class of nAbs that most contributes to the immune response is able to bind the spike protein in its closed conformation. | nabs | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 5 | Although this class of nAbs only partially inhibits the spike protein binding to the host"s angiotensin converting enzyme 2 (ACE2), it has been suggested to lock the closed pre-fusion spike protein conformation and therefore prevent its transition to an open state. | nabs | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 6 | Although this class of nAbs only partially inhibits the spike protein binding to the host"s angiotensin converting enzyme 2 (ACE2), it has been suggested to lock the closed pre-fusion spike protein conformation and therefore prevent its transition to an open state. | nabs | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |