Title : Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes.

Pub. Date : 2022 Feb 18

PMID : 35204825






1 Functional Relationships(s)
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1 Redox sensitivity of p53 functions is supported by (i) thioredoxin-dependent reduction of p53 disulfides, (ii) inhibition of the thioredoxin-dependent deoxyribonucleotide synthesis by p53 binding to RRM2B and (iii) changed intracellular distribution of p53 through its oxidation by CHCHD4 in the mitochondrial intermembrane space. Disulfides thioredoxin Homo sapiens