Title : Transgenic Mouse Overexpressing Spermine Oxidase in Cerebrocortical Neurons: Astrocyte Dysfunction and Susceptibility to Epileptic Seizures.

Pub. Date : 2022 Jan 25

PMID : 35204705






2 Functional Relationships(s)
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Protein Name
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1 Spermine oxidase, specifically oxidized spermine, is a neuromodulator of several types of ion channel and ionotropic glutamate receptors, and its deregulated activity has been linked to several brain pathologies, including epilepsy. Spermine spermine oxidase Mus musculus
2 The Dach-SMOX mouse line was generated using a Cre/loxP-based recombination approach to study the complex and critical functions carried out by spermine oxidase and spermine in the mammalian brain. Spermine spermine oxidase Mus musculus