Title : Operational tolerance after hematopoietic stem cell transplantation is characterized by distinct transcriptional, phenotypic, and metabolic signatures.

Pub. Date : 2022 Feb 23

PMID : 35196024






2 Functional Relationships(s)
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1 RNA sequencing analyses highlighted modifications in the tolerant patients" transcriptomic profiles, particularly with overexpression of the ectoenzyme NT5E (encoding CD73), which could counterbalance CD38 enzymatic functions by producing adenosine. Adenosine CD38 molecule Homo sapiens
2 Thus, balance between a CD38-activated immune state and CD73-related production of adenosine may be a key regulator of operational tolerance. Adenosine CD38 molecule Homo sapiens