Title : Engineering of regulatory T cells by means of mRNA electroporation in a GMP-compliant manner.

Pub. Date : 2022 Jun

PMID : 35193826






2 Functional Relationships(s)
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1 First, a soluble polymer conjugated with antibodies to CD3 and CD28 and high amounts of exogenous IL-2 for in vitro Treg expansion resulted in a >70-fold and 185-fold increase of a pure population of CD4+CD127-CD25hi Tregs and CD4+CD127-CD25+CD45RA+ Tregs, respectively. treg interleukin 7 receptor Homo sapiens
2 First, a soluble polymer conjugated with antibodies to CD3 and CD28 and high amounts of exogenous IL-2 for in vitro Treg expansion resulted in a >70-fold and 185-fold increase of a pure population of CD4+CD127-CD25hi Tregs and CD4+CD127-CD25+CD45RA+ Tregs, respectively. treg interleukin 7 receptor Homo sapiens