Pub. Date : 2022 Apr 25
PMID : 35191576
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The interaction of the SARS CoV2 spike glycoprotein with two sialic acid-containing trisaccharides (a2,3 and a2,6 sialyl N-Acetyllactosamine) has been demonstrated by NMR. | N-Acetylneuraminic Acid | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
2 | The NMR-based distinction between the signals of those sialic acids in the glycans covalently attached to the spike protein and those belonging to the exogenous a2,3 and a2,6 sialyl N-Acetyllactosamine ligands has been achieved by synthesizing uniformly 13C-labelled trisaccharides at the sialic acid and galactose moieties. | N-Acetylneuraminic Acid | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
3 | Additional experiments with the spike protein in the presence of a specific antibody for the N-terminal domain and with the isolated receptor binding and N-terminal domains of the spike protein unambiguously show that the sialic acid binding site is located at the N-terminal domain. | N-Acetylneuraminic Acid | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
4 | Additional experiments with the spike protein in the presence of a specific antibody for the N-terminal domain and with the isolated receptor binding and N-terminal domains of the spike protein unambiguously show that the sialic acid binding site is located at the N-terminal domain. | N-Acetylneuraminic Acid | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |