Title : ALDH3A1 overexpression in OSCC inhibits inflammation via phospho-Ser727 at STAT3 in tumor-associated macrophages.

Pub. Date : 2022 Feb 21

PMID : 35188323






2 Functional Relationships(s)
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1 The phosphorylation of STAT3 and the TLR4/TRAF6/TBK1 cascade reaction in TAMs were analyzed using western blotting, and mitochondrial ROS (mtROS) production was measured using a MitoSox kit. tams toll like receptor 4 Homo sapiens
2 RESULTS: ALDH3A1 attenuated STAT3 phosphorylation at Ser727 rapidly and mtROS production earlier in TAMs via inhibiting TLR4/TRAF6/TBK1 cascade reaction. tams toll like receptor 4 Homo sapiens