Pub. Date : 2022 Mar 22
PMID : 35179349
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein, a tumor immune-microenvironment reshaped hybrid nanocage CPN-NLI/MLD coloaded with the Bruton"s tyrosine kinase inhibitor ibrutinib, and cytotoxic drug docetaxel was developed for stepwise targeting TIBs and tumor cells, respectively. | ibrutinib | Bruton tyrosine kinase | Homo sapiens |
| 2 | The boosted antitumor immunity was achieved mainly by the inhibition of Bruton"s tyrosine kinase activation mediated by ibrutinib, which reduced the proportion of TIBs, enhanced infiltration of CD8+ and CD4+ T cells, increased the secretion of immunogenic cytokines including IL-2 and IFN-gamma, and inhibited the proliferation of regulatory T cells and secretion of immunosuppressive cytokines including IL-10, IL-4, and TGF-beta. | ibrutinib | Bruton tyrosine kinase | Homo sapiens |