Title : Celecoxib Synergistically Enhances MLN4924-Induced Cytotoxicity and EMT Inhibition Via AKT and ERK Pathways in Human Urothelial Carcinoma.

Pub. Date : 2022 Jan-Dec

PMID : 35176901






2 Functional Relationships(s)
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1 This study examined the synergistic effect of celecoxib, a cyclooxygenase-2 (COX-2) selective inhibitor, on MLN4924-induced cytotoxicity and epithelial-mesenchymal transition (EMT) inhibition via AKT and ERK pathways in human UC. Celecoxib AKT serine/threonine kinase 1 Homo sapiens
2 Briefly, a combination of MLN4924 and celecoxib reduced the protein expression of p-AKT(S473) and p-ERK in UC cell lines. Celecoxib AKT serine/threonine kinase 1 Homo sapiens