Title : Relative Contributions of Pseudohypoxia and Inflammation to Peritoneal Alterations with Long-Term Peritoneal Dialysis Patients.

Pub. Date : 2022 Feb 15

PMID : 35168992






2 Functional Relationships(s)
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1 The glucose- induced high NADH/NAD+ ratio upregulates the hypoxia-inducible factor-1 gene, which stimulates not only the glucose transporter-1 gene, but also many profibrotic genes like TGFbeta, VEGF, PAI-1 and CTGF, all known to be involved in the development of peritoneal fibrosis. Glucose vascular endothelial growth factor A Homo sapiens
2 The glucose- induced high NADH/NAD+ ratio upregulates the hypoxia-inducible factor-1 gene, which stimulates not only the glucose transporter-1 gene, but also many profibrotic genes like TGFbeta, VEGF, PAI-1 and CTGF, all known to be involved in the development of peritoneal fibrosis. Glucose vascular endothelial growth factor A Homo sapiens