Title : Drug repurposing of adapalene for melanoma treatment.

Pub. Date : 2022 Jan

PMID : 35168402






1 Functional Relationships(s)
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1 Adapalene demonstrated antiproliferative activity in melanoma cell lines via S-phase arrest-dependent apoptosis mediated by DNA damage through an increase in the expression of p-ATM and p-chk2 and a decrease in the expression of p-BRCA1 and Rad51. Adapalene checkpoint kinase 2 Homo sapiens