Pub. Date : 2022 Feb 4
PMID : 35163722
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the liver, cholesterol is metabolized to bile acids by cytochrome P450, family 7, subfamily a, polypeptide 1 (CYP7A1), the transcription of which is negatively regulated by the ERK pathway. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 2 | In the liver, cholesterol is metabolized to bile acids by cytochrome P450, family 7, subfamily a, polypeptide 1 (CYP7A1), the transcription of which is negatively regulated by the ERK pathway. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 3 | These results indicate that taurine promotes cholesterol metabolism by suppressing the FGF21/ERK pathway followed by upregulating Cyp7a1 expression. | Cholesterol | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |