Pub. Date : 2022 Jan 31
PMID : 35163553
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In U-2 OS cells with wild-type tumor suppressor p53, we found that hinokitiol exposure induced p53 expression and cellular senescence, and knockdown of p53 suppressed the senescence. | beta-thujaplicin | tumor protein p53 | Homo sapiens |
| 2 | In U-2 OS cells with wild-type tumor suppressor p53, we found that hinokitiol exposure induced p53 expression and cellular senescence, and knockdown of p53 suppressed the senescence. | beta-thujaplicin | tumor protein p53 | Homo sapiens |
| 3 | However, in MG-63 cells with mutated p53, a high percentage of cells underwent apoptosis with cleaved-PARP expression and Annexin V staining after hinokitiol treatment. | beta-thujaplicin | tumor protein p53 | Homo sapiens |
| 4 | As the autophagy was suppressed through the autophagy inhibitor chloroquine, hinokitiol-induced senescence in U-2 OS cells was significantly enhanced accompanying more abundant p53 expression. | beta-thujaplicin | tumor protein p53 | Homo sapiens |